Purpose: Urinary pH is an important factor linked to renal stone disease and a useful marker in the treatment of\nurolithiasis. Although the gold standard for measuring urinary pH utilizes a glass electrode and a pH meter, at\npresent dipstick testing is largely used to estimate urinary pH. However, the accuracy and precision of this method\nmay be insufficient for making clinical decisions in patients with lithiasis. The aim of this study is to describe a new\ndevice for urinary pH testing.\nMethods: The device includes a pH sensor based on differential measurement of an ISFET-REFET pair. The drawbacks\nassociated with this type of configuration, namely short lifetime and manual fabrication, have been overcome in\nthe prototype. An automatic one point calibration is performed when turning on the system. Two buffer solutions\nwere utilized to determine the intra- and inter-day precision of the device. The pH of 30 fresh human urine\nsamples was measured using a pH-meter, a dipstick and the new electronic device.\nResults: In some cases, dipstick measurements differed from those of the pH meter by more than 0.40 units, a\nclinically relevant discrepancy, whereas none of the measurements made with the new electronic device differed\nfrom the results of the pH-meter by more than 0.1 pH units.\nConclusions: This new electronic device has the possibility to be used by stone-formers to control their urinary\npH at home, increasing the tools available for stone prevention and prophylaxis
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